Title:	Allogeneic Venous Grafts of Different Origin Used for Portal Vein Reconstruction After Pancreaticoduodenectomy – Experimental Study
Authors:	Pálek, Richard Jonášová, Alena Rosendorf, Jáchym Mik, Patrik Bajcurová, Kristýna Hošek, Petr Moulisová, Vladimíra Eberlová, Lada Haidingerová, Lenka Brzoň, Ondřej Bednář, Lukáš Kříž, Tomáš Dolanský, Martin Třeška, Vladislav Tonar, Zbyněk Vimmr, Jan Liška, Václav
Citation:	PÁLEK, R., JONÁŠOVÁ, A., ROSENDORF, J., MIK, P., BAJCUROVÁ, K., HOŠEK, P., MOULISOVÁ, V., EBERLOVÁ, L., HAIDINGEROVÁ, L., BRZOŇ, O., BEDNÁŘ, L., KŘÍŽ, T., DOLANSKÝ, M., TŘEŠKA, V., TONAR, Z., VIMMR, J., LIŠKA, V. Allogeneic Venous Grafts of Different Origin Used for Portal Vein Reconstruction After Pancreaticoduodenectomy – Experimental Study. ANTICANCER RESEARCH, 2019, roč. 39, č. 12, s. 6603-6620. ISSN 0250-7005.
Issue Date:	2019
Publisher:	International Institute of Anticancer Research
Document type:	článek article
URI:	2-s2.0-85076264760 http://hdl.handle.net/11025/39533
ISSN:	0250-7005
Keywords in different language:	pancreaticoduodenectomy;portal vein reconstruction;allogeneic grafts;portal vein haemodynamics;computer blood flow simulation
Abstract in different language:	Background: In clinical medicine, little is known about the use of allografts for portal vein (PV) reconstruction after pancreaticoduodenectomy (PD). Portal and caval systems are physiologically different, therefore the properties of allografts from caval and portal systems were studied here in a pig model. Materials and Methods: PD with PV reconstruction with allogeneic venous graft from PV or inferior vena cava (IVC) was performed in 26 pigs. Biochemical analysis and ultrasonography measurements were performed during a 4-week monitoring period. Computer simulations were used to evaluate haemodynamics in reconstructed PV and explanted allografts were histologically examined. Results: The native PV and IVC grafts varied in histological structure but were able to adapt morphologically after transplantation. Computer simulation suggested PV grafts to be more susceptible to thrombosis development. Thrombosis of reconstructed PV occurred in four out of five cases in PV group. Conclusion: This study supports the use of allografts from caval system for PV reconstruction in clinical medicine when needed.
Rights:	Plný text je přístupný v rámci univerzity přihlášeným uživatelům. © International Institute of Anticancer Research
Appears in Collections:	Články / Articles (KME) OBD

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