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dc.contributor.authorDodda, Jagan Mohan
dc.contributor.authorRemiš, Tomáš
dc.contributor.authorRotimi, Sadiku
dc.contributor.authorYeh, Yi-Cheun
dc.date.accessioned2022-09-12T10:00:26Z-
dc.date.available2022-09-12T10:00:26Z-
dc.date.issued2022
dc.identifier.citationDODDA, JM. REMIŠ, T. ROTIMI, S. YEH, Y. Progress in the drug encapsulation of poly(lactic-co-glycolic acid) and folate-decorated poly(ethylene glycol)-poly(lactic-co-glycolic acid) conjugates for selective cancer treatment. Journal of Materials Chemistry B: Materials for biology and medicine, 2022, roč. 10, č. 22, s. 4127-4141. ISSN: 2050-750Xcs
dc.identifier.issn2050-750X
dc.identifier.uri2-s2.0-85131772236
dc.identifier.urihttp://hdl.handle.net/11025/49652
dc.format15 s.cs
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.relation.ispartofseriesJournal of Materials Chemistry B: Materials for biology and medicineen
dc.rightsPlný text není přístupný.cs
dc.rights© Royal Society of Chemistryen
dc.titleProgress in the drug encapsulation of poly(lactic-co-glycolic acid) and folate-decorated poly(ethylene glycol)-poly(lactic-co-glycolic acid) conjugates for selective cancer treatmenten
dc.typečlánekcs
dc.typearticleen
dc.rights.accessclosedAccessen
dc.type.versionpublishedVersionen
dc.description.abstract-translatedPoly(lactic-co-glycolic acid) (PLGA) is a US Food and Drug Administration (FDA)-approved polymer used in humans in the forms of resorbable sutures, drug carriers, and bone regeneration materials. Recently, PLGA-based conjugates have been extensively investigated for cancer, which is the second leading cause of death globally. This article presents an account of the literature on PLGA-based conjugates, focusing on their chemistries, biological activity, and functions as targeted drug carriers or sustained drug controllers for common cancers (e.g., breast, prostate, and lung cancers). The preparation and drug encapsulation of PLGA nanoparticles and folate-decorated poly(ethylene glycol)–poly(lactic-co-glycolic acid) (FA–PEG–PLGA) conjugates are discussed, along with several representative examples. Particularly, the reactions used for preparing drug-conjugated PLGA and FA–PEG–PLGA are emphasized, with the associated chemistries involved in the formation of structures and their biocompatibility with internal organs. This review provides a deeper understanding of the constituents and interactions of PLGA-conjugated materials to ensure successful conjugation in PLGA material design and the subsequent biomedical applications.en
dc.subject.translatedpoly(lacticco- glycolic acid)en
dc.subject.translatedcancer treatmenten
dc.subject.translateddrug encapsulationen
dc.identifier.doi10.1039/D2TB00469K
dc.type.statusPeer-revieweden
dc.identifier.document-number797958300001
dc.identifier.obd43936542
dc.project.IDEF17_048/0007280/Aplikace moderních technologií v medicíně a průmyslucs
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