Title:	Common, Intermediate and Well-Documented HLA Alleles in World Populations: CIWD Version 3.0.0
Authors:	Hurley, Carolyn K. Kempenich, Jane Wadsworth, Kim Sauter, Jürgen Hofmann, Jan A. Schefzyk, Daniel Schmidt, Alexander A. Galarza, Pablo Cardozo, Maria B.R. Dudkiewicz, Malgorzata Houdová, Lucie Jindra, Pavel Sorensen, Betina S. Jagannathan, Latha Mathur, Ankit Linjama, Tiina Torosian, Tigran Freudenberger, Rafi Manolis, Anastasios Mavrommatis, John Cereb, Nezih Manor, Sigal Shriki, Nira Sacchi, Nicoletta Ameen, Reem Fisher, Raewyn Dunckley, Heather Andersen, Irene Alaskar, Ahmed Alzahrani, Mohsen Hajeer, Ali Jawdat, Dunia Nicoloso, Grazia Kupatawintu, Pawinee Cho, Louise Kaur, Ashminder Bengtsson, Mats Dehn, Jason
Citation:	HURLEY, C. K., KEMPENICH, J., WADSWORTH, K., SAUTER, J., HOFMANN, J. A., SCHEFZYK, D., SCHMIDT, A. A., GALARZA, P., CARDOZO, M. B., DUDKIEWICZ, M., HOUDOVÁ, L., JINDRA, P., SORENSEN, B. S., JAGANNATHAN, L., MATHUR, A., LINJAMA, T., TOROSIAN, T., FREUDENBERGER, R., MANOLIS, A., MAVROMMATIS, J., CEREB, N., MANOR, S., SHRIKI, N., SACCHI, N., AMEEN, R., FISHER, R., DUNCKLEY, H., ANDERSEN, I., ALASKAR, A., ALZAHRANI, M., HAJEER, A., JAWDAT, D., NICOLOSO, G., KUPATAWINTU, P., CHO, L., KAUR, A., BENGTSSON, M., DEHN, J. Common, Intermediate and Well-Documented HLA Alleles in World Populations: CIWD Version 3.0.0. Hla, 2020, roč. 95, č. 6, s. 516-531. ISSN 2059-2302.
Issue Date:	2020
Publisher:	Blackwell Publishing
Document type:	článek article
URI:	2-s2.0-85078839466 http://hdl.handle.net/11025/42601
ISSN:	2059-2302
Keywords in different language:	CIWD catalogue;HLA;alleles;population genetics;ethnic groups, gene frequency
Abstract in different language:	A catalog of common, intermediate and well-documented (CIWD) HLA-A, -B, -C, -DRB1, -DRB3, -DRB4, -DRB5, -DQB1 and -DPB1 alleles has been compiled from over 8 million individuals using data from 20 unrelated hematopoietic stem cell volunteer donor registries. Individuals are divided into seven geographic/ancestral/ethnic groups and data are summarized for each group and for the total population. P (two-field) and G group assignments are divided into one of four frequency categories: common (≥1 in 10 000), intermediate (≥1 in 100 000), well-documented (≥5 occurrences) or not-CIWD. Overall 26% of alleles in IPD-IMGT/HLA version 3.31.0 at P group resolution fall into the three CIWD categories. The two-field catalog includes 18% (n = 545) common, 17% (n = 513) intermediate, and 65% (n = 1997) well-documented alleles. Full-field allele frequency data are provided but are limited in value by the variations in resolution used by the registries. A recommended CIWD list is based on the most frequent category in the total or any of the seven geographic/ancestral/ethnic groups. Data are also provided so users can compile a catalog specific to the population groups that they serve. Comparisons are made to three previous CWD reports representing more limited population groups. This catalog, CIWD version 3.0.0, is a step closer to the collection of global HLA frequencies and to a clearer view of HLA diversity in the human population as a whole.
Rights:	© Blackwell Publishing
Appears in Collections:	Články / Articles (NTIS) OBD

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