Title: Thin-layer hydroxyapatite deposition on a nanofiber surface stimulates mesenchymal stem cell proliferation and their differentiation into osteoblasts
Authors: Prosecká, Eva
Buzgo, Matej
Rampichová, Michala
Kocourek, Tomáš
Kochová, Petra
Vysloužilová, Lucie
Tvrdík, Daniel
Jelínek, Miroslav
Citation: Journal of Biomedicine and Biotechnology. 2012, article id: 428503.
Issue Date: 2012
Publisher: Hindawi Publishing
Document type: článek
URI: http://www.hindawi.com/journals/bmri/2012/428503/
ISSN: 1110-7243
Keywords: tenké vrstvy;pulzní laserová depozice;nanovlákna
Keywords in different language: nanofibres;thin layers;pulse laser deposition
Abstract: Pulsed laser deposition was proved as a suitable method for hydroxyapatite (HA) coating of coaxial poly-ε-caprolactone/polyvinylalcohol (PCL/PVA) nanofibers. The fibrous morphology of PCL/PVA nanofibers was preserved, if the nanofiber scaffold was coated with thin layers of HA (200nm and 400 nm). Increasing thickness of HA, however, resulted in a gradual loss of fibrous character. In addition, biomechanical properties were improved after HA deposition on PCL/PVA nanofibers as the value of Young’s moduli of elasticity significantly increased. Clearly, thin-layer hydroxyapatite deposition on a nanofiber surface stimulated mesenchymal stem cell viability and their differentiation into osteoblasts. The optimal depth of HA was 800 nm.
Rights: © 2012 Eva Prosecká et al.
Appears in Collections:Články / Articles (NTIS)

Files in This Item:
File Description SizeFormat 
jbb.pdf581,14 kBAdobe PDFView/Open

Please use this identifier to cite or link to this item: http://hdl.handle.net/11025/1754

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.